منابع مشابه
FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis
Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance. Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR). Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated...
متن کاملfoxp3 and tgf-β gene polymorphisms in allergic rhinitis
background: regulatory cd4+t (treg) cells are effective in maintaining immune tolerance. objective: to investigate single nucleotide polymorphisms (snps) of transforming growth factor β-1 (tgf-β1) and forkhead box protein 3 (foxp3) genes in iranian patients with allergic rhinitis (ar). methods: variations at codons 10 and 25 of tgf-β1 and foxp3 at positions -3279 a>c and -924 a>g were evaluated...
متن کاملIκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.
Constitutive activation of the nuclear factor-κ B (NF-κB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-κB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, it remains unclear how specific target genes are regulated. We identified the atypical nuclear IκB pro...
متن کاملAll-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus
BACKGROUND It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-β-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. Our objective, therefore, was to determine how atRA promotes the differentiation of iTregs. METHODOLOGY/PRINCIPAL FINDINGS Ad...
متن کاملTGF-β Induces Surface LAP Expression on Murine CD4 T Cells Independent of Foxp3 Induction
BACKGROUND It has been reported that human FOXP3(+) CD4 Tregs express GARP-anchored surface latency-associated peptide (LAP) after activation, based on the use of an anti-human LAP mAb. Murine CD4 Foxp3(+) Tregs have also been reported to express surface LAP, but these studies have been hampered by the lack of suitable anti-mouse LAP mAbs. METHODOLOGY/PRINCIPAL FINDINGS We generated anti-mous...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2015
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2015.07.013